Biodistribution, Tumor Detection, and Radiation Dosimetry of (18)F-5-Fluoro-2′-Deoxycytidine with Tetrahydrouridine in Solid Tumors

In preclinical studies, 5-fluoro-2′-deoxycytidine (FdCyd), an inhibitor of DNA methyltransferase and DNA hypermethylation, has shown treatment efficacy against multiple malignancies by suppressing epigenetic hypermethylation in tumor cells. Several ongoing clinical trials are using FdCyd, and althou...

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Vydáno v:J Nucl Med
Hlavní autoři: Young, Colin R., Adler, Stephen, Eary, Janet F., Lindenberg, M. Liza, Jacobs, Paula M., Collins, Jerry, Kummar, Shivaani, Kurdziel, Karen A., Choyke, Peter L., Mena, Esther
Médium: Artigo
Jazyk:Inglês
Vydáno: Society of Nuclear Medicine 2019
Témata:
Oncology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6448462/
https://ncbi.nlm.nih.gov/pubmed/30389817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2967/jnumed.118.216994
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