Stability of 5-Fluoro-2′-deoxycytidine and Tetrahydrouridine in Combination

In vivo, the DNA methyltransferase inhibitor, 5-fluoro-2′-deoxycytidine (FdCyd, NSC-48006), is rapidly converted to its unwanted metabolites. Tetrahydrouridine (THU, NSC-112907), a cytidine deaminase inhibitor can block the first metabolic step in FdCyd catabolism. Clinical studies have shown that c...

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Detalhes bibliográficos
Main Authors: Guo, Duoli, Myrdal, Paul B., Karlage, Kelly L., O’Connell, Sean P., Wissinger, Travis J., Tabibi, S. Esmail, Yalkowsky, Samuel H.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2850501/
https://ncbi.nlm.nih.gov/pubmed/20151336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12249-010-9383-2
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