NCI Comparative Oncology Program Testing of Indenoisoquinoline Topoisomerase I Inhibitors in Naturally Occurring Canine Lymphoma

PURPOSE: Only one chemical class of topoisomerase I (TOP1) inhibitors is FDA approved, the camptothecins with irinotecan and topotecan widely used. Because of their limitations (chemical instability, drug efflux-mediated resistance, and diarrhea), novel TOP1 inhibitors are warranted. Indenoisoquinol...

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Udgivet i:Clin Cancer Res
Main Authors: Burton, Jenna H., Mazcko, Christina, Leblanc, Amy, Covey, Joseph M., Ji, Jiuping, Kinders, Robert J., Parchment, Ralph E., Khanna, Chand, Paoloni, Melissa, Lana, Sue, Weishaar, Kristen, London, Cheryl, Kisseberth, William, Krick, Erika, Vail, David, Childress, Michael, Bryan, Jeffrey, Baber, Lisa, Ehrhart, E.J., Kent, Michael, Fan, Timothy, Kow, Kelvin, Northup, Nicole, Wilson-Robles, Heather, Tomaszewski, Joseph, Holleran, Julianne L., Muzzio, Miguel, Eiseman, Julie, Beumer, Jan H., Doroshow, James H., Pommier, Yves
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6312717/
https://ncbi.nlm.nih.gov/pubmed/30061364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-1498
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