NCI Comparative Oncology Program Testing of Indenoisoquinoline Topoisomerase I Inhibitors in Naturally Occurring Canine Lymphoma

PURPOSE: Only one chemical class of topoisomerase I (TOP1) inhibitors is FDA approved, the camptothecins with irinotecan and topotecan widely used. Because of their limitations (chemical instability, drug efflux-mediated resistance, and diarrhea), novel TOP1 inhibitors are warranted. Indenoisoquinol...

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Bibliografische gegevens
Gepubliceerd in:Clin Cancer Res
Hoofdauteurs: Burton, Jenna H., Mazcko, Christina, Leblanc, Amy, Covey, Joseph M., Ji, Jiuping, Kinders, Robert J., Parchment, Ralph E., Khanna, Chand, Paoloni, Melissa, Lana, Sue, Weishaar, Kristen, London, Cheryl, Kisseberth, William, Krick, Erika, Vail, David, Childress, Michael, Bryan, Jeffrey, Baber, Lisa, Ehrhart, E.J., Kent, Michael, Fan, Timothy, Kow, Kelvin, Northup, Nicole, Wilson-Robles, Heather, Tomaszewski, Joseph, Holleran, Julianne L., Muzzio, Miguel, Eiseman, Julie, Beumer, Jan H., Doroshow, James H., Pommier, Yves
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6312717/
https://ncbi.nlm.nih.gov/pubmed/30061364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-1498
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