NCI Comparative Oncology Program Testing of Indenoisoquinoline Topoisomerase I Inhibitors in Naturally Occurring Canine Lymphoma

PURPOSE: Only one chemical class of topoisomerase I (TOP1) inhibitors is FDA approved, the camptothecins with irinotecan and topotecan widely used. Because of their limitations (chemical instability, drug efflux-mediated resistance, and diarrhea), novel TOP1 inhibitors are warranted. Indenoisoquinol...

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Publicado no:Clin Cancer Res
Main Authors: Burton, Jenna H., Mazcko, Christina, Leblanc, Amy, Covey, Joseph M., Ji, Jiuping, Kinders, Robert J., Parchment, Ralph E., Khanna, Chand, Paoloni, Melissa, Lana, Sue, Weishaar, Kristen, London, Cheryl, Kisseberth, William, Krick, Erika, Vail, David, Childress, Michael, Bryan, Jeffrey, Baber, Lisa, Ehrhart, E.J., Kent, Michael, Fan, Timothy, Kow, Kelvin, Northup, Nicole, Wilson-Robles, Heather, Tomaszewski, Joseph, Holleran, Julianne L., Muzzio, Miguel, Eiseman, Julie, Beumer, Jan H., Doroshow, James H., Pommier, Yves
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6312717/
https://ncbi.nlm.nih.gov/pubmed/30061364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-1498
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