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Effects of the aldehyde dehydrogenase inhibitor disulfiram on the plasma pharmacokinetics, metabolism, and toxicity of benzaldehyde dimethane sulfonate (NSC281612, DMS612, BEN) in mice

PURPOSE: Benzaldehyde dimethane sulfonate (DMS612, NSC281612, BEN) is an alkylator with activity against renal cell carcinoma, currently in phase I trials. In blood, BEN is rapidly metabolized into its highly reactive carboxylic acid (BA), presumably the predominant alkylating species. We hypothesiz...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Parise, Robert A., Beumer, Jan H., Clausen, Dana M., Rigatti, Lora H., Ziegler, Judy A., Gasparetto, Maura, Smith, Clayton A, Eiseman, Julie L.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2013
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3836906/
https://ncbi.nlm.nih.gov/pubmed/24061865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-013-2296-5
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