Perturbation of the c-Myc–Max Protein–Protein Interaction via Synthetic α-Helix Mimetics

The rational design of inhibitors of the bHLH-ZIP oncoprotein c-Myc is hampered by a lack of structure in its monomeric state. We describe herein the design of novel, low-molecular-weight, synthetic α-helix mimetics that recognize helical c-Myc in its transcriptionally active coiled-coil structure i...

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Publicado no:J Med Chem
Main Authors: Jung, Kwan-Young, Wang, Huabo, Teriete, Peter, Yap, Jeremy L., Chen, Lijia, Lanning, Maryanna E., Hu, Angela, Lambert, Lester J., Holien, Toril, Sundan, Anders, Cosford, Nicholas, Prochownik, Edward V., Fletcher, Steven
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4955407/
https://ncbi.nlm.nih.gov/pubmed/25734936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm501440q
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