Structural Re-Engineering of the α-Helix Mimetic JY-1-106 into Small-Molecules: Disruption of the Mcl-1–Bak-BH3 Protein–Protein Interaction with 2,6-Di-Substituted Nicotinates

The disruption of aberrant protein–protein interactions (PPI) with synthetic agents remains a challenging goal in contemporary medicinal chemistry but some progress has been made. One such dysregulated PPI is that between the anti-apoptotic Bcl-2 proteins, including Mcl-1, and the α-helical BH3 doma...

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Veröffentlicht in:ChemMedChem
Hauptverfasser: Drennen, Brandon, Scheenstra, Jacob A., Yap, Jeremy L., Chen, Lijia, Lanning, Maryanna E., Roth, B. M., Wilder, Paul T., Fletcher, Steven
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4838500/
https://ncbi.nlm.nih.gov/pubmed/26844930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201500461
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