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Structural Re-Engineering of the α-Helix Mimetic JY-1-106 into Small-Molecules: Disruption of the Mcl-1–Bak-BH3 Protein–Protein Interaction with 2,6-Di-Substituted Nicotinates
The disruption of aberrant protein–protein interactions (PPI) with synthetic agents remains a challenging goal in contemporary medicinal chemistry but some progress has been made. One such dysregulated PPI is that between the anti-apoptotic Bcl-2 proteins, including Mcl-1, and the α-helical BH3 doma...
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| Pubblicato in: | ChemMedChem |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4838500/ https://ncbi.nlm.nih.gov/pubmed/26844930 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201500461 |
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