Phosphonoxins III: Synthesis of α-Aminophosphonate Analogs of Antifungal Polyoxins with Anti-Giardia activity

Por Staake, Michael, Chauhan, Jay, Zhou, Ding, Shanker, Aaron, De Chatterjee, Atasi, Das, Siddhartha, Patterson, Steven E.
Publicado em 2010

Discovery of Methyl 4′-Methyl-5-(7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)-[1,1′-biphenyl]-3-carboxylate, an Improved Small-Molecule Inhibitor of c-Myc–Max Dimerization

Por Chauhan, Jay, Wang, Huabo, Yap, Jeremy L., Sabato, Philip E., Hu, Angela, Prochownik, Edward V., Fletcher, Steven
Publicado em 2014

Optimization of a Benzothiazole Indolene Scaffold Targeting Bacterial Cell Wall Assembly

Por Chauhan, Jay, Yu, Wenbo, Cardinale, Steven, Opperman, Timothy J, MacKerell, Alexander D, Fletcher, Steven, de Leeuw, Erik PH
Publicado no Drug Des Devel Ther (2020)

Pharmacophore identification of c-Myc inhibitor 10074-G5

Por Yap, Jeremy L., Wang, Huabo, Hu, Angela, Chauhan, Jay, Jung, Kwan-Young, Gharavi, Robert B., Prochownik, Edward V., Fletcher, Steven
Publicado em 2012

Anti-HIV-1 Activity of Resveratrol Derivatives and Synergistic Inhibition of HIV-1 by the Combination of Resveratrol and Decitabine

Por Clouser, Christine L., Chauhan, Jay, Bess, Matthew A., van Oploo, Jessica, Zhou, Ding, Dimick-Gray, Sarah, Mansky, Louis M., Patterson, Steven E.
Publicado em 2012

Structure–activity exploration of a small-molecule Lipid II inhibitor

Por Fletcher, Steven, Yu, Wenbo, Huang, Jing, Kwasny, Steven M, Chauhan, Jay, Opperman, Timothy J, MacKerell, Alexander D, de Leeuw, Erik PH
Publicado no Drug Des Devel Ther (2015)

Analysis of the Ex Vivo and In Vivo Antiretroviral Activity of Gemcitabine

Por Clouser, Christine L., Holtz, Colleen M., Mullett, Mary, Crankshaw, Duane L., Briggs, Jacquie E., Chauhan, Jay, VanHoutan, Ilze Matise, Patterson, Steven E., Mansky, Louis M.
Publicado em 2011

Disruption of Myc-Max Heterodimerization with Improved Cell-Penetrating Analogs of the Small Molecule 10074-G5

Por Wang, Huabo, Chauhan, Jay, Hu, Angela, Pendleton, Kelsey, Yap, Jeremy L., Sabato, Philip E., Jones, Jace W., Perri, Mariarita, Yu, Jianshi, Cione, Erika, Kane, Maureen A., Fletcher, Steven, Prochownik, Edward V.
Publicado em 2013

Synthetic, structural mimetics of the β-hairpin flap of HIV-1 protease inhibit enzyme function

Por Chauhan, Jay, Chen, Shen-En, Fenstermacher, Katherine J., Naser-Tavakolian, Aurash, Reingewertz, Tali, Salmo, Rosene, Lee, Christian, Williams, Emori, Raje, Mithun, Sundberg, Eric, DeStefano, Jeffrey J., Freire, Ernesto, Fletcher, Steven
Publicado no Bioorg Med Chem (2015)

Erratum: Disruption of Myc-Max Heterodimerization with Improved Cell-Penetrating Analogs of the Small Molecule 10074-G5

Por Wang, Huabo, Chauhan, Jay, Hu, Angela, Pendleton, Kelsey, Yap, Jeremy L., Sabato, Philip E., Jones, Jace W., Perri, Mariarita, Yu, Jianshi, Cione, Erika, Kane, Maureen A., Fletcher, Steven, Prochownik, Edward V.
Publicado no Oncotarget (2018)

Inhibition of TLR2 signaling by small molecule inhibitors targeting a pocket within the TLR2 TIR domain

Por Mistry, Pragnesh, Laird, Michelle H. W., Schwarz, Ryan S., Greene, Shannon, Dyson, Tristan, Snyder, Greg A., Xiao, Tsan Sam, Chauhan, Jay, Fletcher, Steven, Toshchakov, Vladimir Y., MacKerell, Alexander D., Vogel, Stefanie N.
Publicado no Proc Natl Acad Sci U S A (2015)

Structural Modifications of (Z)-3-(2-aminoethyl)-5-(4-ethoxybenzylidene)thiazolidine-2,4-dione that Improve Selectivity for the Inhibition of Melanoma Cells Containing Active ERK S...

Por Jung, Kwan-Young, Samadani, Ramin, Chauhan, Jay, Nevels, Kerrick, Yap, Jeremy L., Zhang, Jun, Worlikar, Shilpa, Lanning, Maryanna E., Chen, Lijia, Ensey, Mary, Shukla, Sagar, Salmo, Rosene, Heinzl, Geoffrey, Gordon, Caryn, Dukes, Troy, MacKerell, Alexander D., Shapiro, Paul, Fletcher, Steven
Publicado em 2013

Nanotherapy delivery of c-myc inhibitor targets Protumor Macrophages and preserves Antitumor Macrophages in Breast Cancer

Por Esser, Alison K., Ross, Michael H., Fontana, Francesca, Su, Xinming, Gabay, Ariel, Fox, Gregory C., Xu, Yalin, Xiang, Jingyu, Schmieder, Anne H., Yang, Xiaoxia, Cui, Grace, Scott, Michael, Achilefu, Samuel, Chauhan, Jay, Fletcher, Steven, Lanza, Gregory M., Weilbaecher, Katherine N.
Publicado no Theranostics (2020)

Structure-Based Design of N-Substituted 1-Hydroxy-4-sulfamoyl-2-naphthoates as Selective Inhibitors of the Mcl-1 Oncoprotein

Por Lanning, Maryanna E., Yu, Wenbo, Yap, Jeremy L., Chauhan, Jay, Chen, Lijia, Whiting, Ellis, Pidugu, Lakshmi S., Atkinson, Tyler, Bailey, Hala, Li, Willy, Roth, Braden M., Hynicka, Lauren, Chesko, Kirsty, Toth, Eric A., Shapiro, Paul, MacKerell, Alexander D., Wilder, Paul T., Fletcher, Steven
Publicado no Eur J Med Chem (2016)