Small molecule epigenetic screen identifies novel EZH2 and HDAC inhibitors that target glioblastoma brain tumor-initiating cells

Glioblastoma (GBM) is the most lethal and aggressive adult brain tumor, requiring the development of efficacious therapeutics. Towards this goal, we screened five genetically distinct patient-derived brain-tumor initiating cell lines (BTIC) with a unique collection of small molecule epigenetic modul...

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Detalles Bibliográficos
Publicado en:Oncotarget
Main Authors: Grinshtein, Natalie, Rioseco, Constanza C., Marcellus, Richard, Uehling, David, Aman, Ahmed, Lun, Xueqing, Muto, Osamu, Podmore, Lauren, Lever, Jake, Shen, Yaoqing, Blough, Michael D., Cairncross, Greg J., Robbins, Stephen M., Jones, Steven J., Marra, Marco A., Al-Awar, Rima, Senger, Donna L., Kaplan, David R.
Formato: Artigo
Idioma:Inglês
Publicado: Impact Journals LLC 2016
Assuntos:
Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5312317/
https://ncbi.nlm.nih.gov/pubmed/27449082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10661
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