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Small molecules reveal an alternative mechanism of Bax activation
The pro-apoptotic protein Bax commits a cell to death by permeabilizing the mitochondrial outer membrane (MOM). To obtain small-molecule probes for elucidating the molecular mechanism(s) of Bax activation, we screened for compounds that induced Bax-mediated liposome permeabilization. We identified f...
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| Publicado no: | Biochem J |
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| Principais autores: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Portland Press Ltd.
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4847155/ https://ncbi.nlm.nih.gov/pubmed/26916338 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20160118 |
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