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Small Molecule Allosteric Inhibitors of BAX
BAX is a critical effector of the mitochondrial cell death pathway in response to a diverse range of stimuli in physiological and disease contexts. Upon binding by BH3-only proteins, cytosolic BAX undergoes conformational activation and translocation, resulting in mitochondrial outer membrane permea...
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| Publicado no: | Nat Chem Biol |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6430685/ https://ncbi.nlm.nih.gov/pubmed/30718816 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-018-0223-0 |
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