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Eltrombopag directly inhibits BAX and prevents cell death
The BCL-2 family protein BAX has essential activity in mitochondrial regulation of cell death. While BAX activity ensures tissue homeostasis, when dysregulated it contributes to aberrant cell death in several diseases. During cellular stress BAX is transformed from an inactive cytosolic conformation...
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| Published in: | Nat Commun |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Nature Publishing Group UK
2021
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7892824/ https://ncbi.nlm.nih.gov/pubmed/33602934 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21224-1 |
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