Synthesis, Optimization, and Evaluation of Novel Small Molecules as Antagonists of WDR5-MLL Interaction

[Image: see text] The WD40-repeat protein WDR5 plays a critical role in maintaining the integrity of MLL complexes and fully activating their methyltransferase function. MLL complexes, the trithorax-like family of SET1 methyltransferases, catalyze trimethylation of lysine 4 on histone 3, and they ha...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Bolshan, Yuri, Getlik, Matthäus, Kuznetsova, Ekaterina, Wasney, Gregory A., Hajian, Taraneh, Poda, Gennadiy, Nguyen, Kong T., Wu, Hong, Dombrovski, Ludmila, Dong, Aiping, Senisterra, Guillermo, Schapira, Matthieu, Arrowsmith, Cheryl H., Brown, Peter J., Al-awar, Rima, Vedadi, Masoud, Smil, David
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2013
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027439/
https://ncbi.nlm.nih.gov/pubmed/24900672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml300467n
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados