PI3K/AKT/mTOR inhibition in combination with doxorubicin is an effective therapy for leiomyosarcoma

BACKGROUND: Leiomyosarcoma (LMS) is a common type of soft tissue sarcoma that responds poorly to standard chemotherapy. Thus the goal of this study was to identify novel selective therapies that may be effective in leiomyosarcoma by screening cell lines with a small molecule library comprised of 480...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:J Transl Med
Main Authors: Babichev, Yael, Kabaroff, Leah, Datti, Alessandro, Uehling, David, Isaac, Methvin, Al-awar, Rima, Prakesch, Michael, Sun, Ren X., Boutros, Paul C., Venier, Rosemarie, Dickson, Brendan C., Gladdy, Rebecca A.
פורמט: Artigo
שפה:Inglês
יצא לאור: BioMed Central 2016
נושאים:
Research
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4782390/
https://ncbi.nlm.nih.gov/pubmed/26952093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-016-0814-z
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