Functional screening of FGFR4-driven tumorigenesis identifies PI3K/mTOR inhibition as a therapeutic strategy in rhabdomyosarcoma

Rhabdomyosarcoma (RMS) is the most common pediatric soft tissue sarcoma and outcomes have stagnated, highlighting a need for novel therapies. Genomic analysis of RMS has revealed that alterations in the receptor tyrosine kinase (RTK)/RAS/PI3K axis are common and that FGFR4 is frequently mutated or o...

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Publicat a:Oncogene
Autors principals: McKinnon, Timothy, Venier, Rosemarie, Yohe, Marielle, Sindiri, Sivasish, Gryder, Berkley E., Shern, Jack F., Kabaroff, Leah, Dickson, Brendan, Schleicher, Krista, Chouinard-Pelletier, Guillaume, Menezes, Serena, Gupta, Abha, Zhang, Xiaohu, Guha, Rajarashi, Ferrer, Marc, Thomas, Craig J., Wei, Yuhong, Davani, Dariush, Guidos, Cynthia J., Khan, Javed, Gladdy, Rebecca A.
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8054765/
https://ncbi.nlm.nih.gov/pubmed/29487419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-017-0122-y
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