Emerging Cellular and Gene Therapies for Congenital Anemias

Por Ludwig, Leif S., Khajuria, Rajiv K., Sankaran, Vijay G.
Publicado no Am J Med Genet C Semin Med Genet (2016)

Longitudinal assessment of clonal mosaicism in human hematopoiesis via mitochondrial mutation tracking

Por Lareau, Caleb A., Ludwig, Leif S., Sankaran, Vijay G.
Publicado no Blood Adv (2019)

Confounding in ex vivo models of Diamond-Blackfan anemia

Por Ulirsch, Jacob C., Lareau, Caleb, Ludwig, Leif S., Mohandas, Narla, Nathan, David G., Sankaran, Vijay G.
Publicado no Blood (2017)

Purifying Selection against Pathogenic Mitochondrial DNA in Human T Cells

Por Walker, Melissa A., Lareau, Caleb A., Ludwig, Leif S., Karaa, Amel, Sankaran, Vijay G., Regev, Aviv, Mootha, Vamsi K.
Publicado no N Engl J Med (2020)

Methylation matters: binding of Ets-1 to the demethylated Foxp3 gene contributes to the stabilization of Foxp3 expression in regulatory T cells

Por Polansky, Julia K., Schreiber, Lisa, Thelemann, Christoph, Ludwig, Leif, Krüger, Melanie, Baumgrass, Ria, Cording, Sascha, Floess, Stefan, Hamann, Alf, Huehn, Jochen
Publicado em 2010

Genome-wide association study follow-up identifies cyclin A2 as a regulator of the transition through cytokinesis during terminal erythropoiesis

Por Ludwig, Leif S., Cho, Hyunjii, Wakabayashi, Aoi, Eng, Jennifer C., Ulirsch, Jacob C., Fleming, Mark D., Lodish, Harvey F., Sankaran, Vijay G.
Publicado no Am J Hematol (2015)

Insight into GATA1 transcriptional activity through interrogation of cis elements disrupted in human erythroid disorders

Por Wakabayashi, Aoi, Ulirsch, Jacob C., Ludwig, Leif S., Fiorini, Claudia, Yasuda, Makiko, Choudhuri, Avik, McDonel, Patrick, Zon, Leonard I., Sankaran, Vijay G.
Publicado no Proc Natl Acad Sci U S A (2016)

X-linked macrocytic dyserythropoietic anemia in females with an ALAS2 mutation

Por Sankaran, Vijay G., Ulirsch, Jacob C., Tchaikovskii, Vassili, Ludwig, Leif S., Wakabayashi, Aoi, Kadirvel, Senkottuvelan, Lindsley, R. Coleman, Bejar, Rafael, Shi, Jiahai, Lovitch, Scott B., Bishop, David F., Steensma, David P.
Publicado no J Clin Invest (2015)

X-linked macrocytic dyserythropoietic anemia in females with an ALAS2 mutation

Por Sankaran, Vijay G., Ulirsch, Jacob C., Tchaikovskii, Vassili, Ludwig, Leif S., Wakabayashi, Aoi, Kadirvel, Senkottuvelan, Lindsley, R. Coleman, Bejar, Rafael, Shi, Jiahai, Lovitch, Scott B., Bishop, David F., Steensma, David P.
Publicado no J Clin Invest (2020)

Transcriptional States and Chromatin Accessibility Underlying Human Erythropoiesis

Por Ludwig, Leif S., Lareau, Caleb A., Bao, Erik L., Nandakumar, Satish K., Muus, Christoph, Ulirsch, Jacob C., Chowdhary, Kaitavjeet, Buenrostro, Jason D., Mohandas, Narla, An, Xiuli, Aryee, Martin J., Regev, Aviv, Sankaran, Vijay G.
Publicado no Cell Rep (2019)

Cyclin D3 coordinates the cell cycle during differentiation to regulate erythrocyte size and number

Por Sankaran, Vijay G., Ludwig, Leif S., Sicinska, Ewa, Xu, Jian, Bauer, Daniel E., Eng, Jennifer C., Patterson, Heide Christine, Metcalf, Ryan A., Natkunam, Yasodha, Orkin, Stuart H., Sicinski, Piotr, Lander, Eric S., Lodish, Harvey F.
Publicado em 2012

Altered translation of GATA1 in Diamond-Blackfan anemia

Por Ludwig, Leif S., Gazda, Hanna T., Eng, Jennifer C., Eichhorn, Stephen W., Thiru, Prathapan, Ghazvinian, Roxanne, George, Tracy I., Gotlib, Jason R., Beggs, Alan H., Sieff, Colin A., Lodish, Harvey F., Lander, Eric S., Sankaran, Vijay G.
Publicado em 2014

Interrogation of human hematopoiesis at single-cell and single-variant resolution

Por Ulirsch, Jacob C., Lareau, Caleb A., Bao, Erik L., Ludwig, Leif S., Guo, Michael H., Benner, Christian, Satpathy, Ansuman T., Kartha, Vinay K., Salem, Rany M., Hirschhorn, Joel N., Finucane, Hilary K., Aryee, Martin J., Buenrostro, Jason D., Sankaran, Vijay G.
Publicado no Nat Genet (2019)

Prioritizing disease and trait causal variants at the TNFAIP3 locus using functional and genomic features

Por Ray, John P., de Boer, Carl G., Fulco, Charles P., Lareau, Caleb A., Kanai, Masahiro, Ulirsch, Jacob C., Tewhey, Ryan, Ludwig, Leif S., Reilly, Steven K., Bergman, Drew T., Engreitz, Jesse M., Issner, Robbyn, Finucane, Hilary K., Lander, Eric S., Regev, Aviv, Hacohen, Nir
Publicado no Nat Commun (2020)

Gene-centric functional dissection of human genetic variation uncovers regulators of hematopoiesis

Por Nandakumar, Satish K, McFarland, Sean K, Mateyka, Laura M, Lareau, Caleb A, Ulirsch, Jacob C, Ludwig, Leif S, Agarwal, Gaurav, Engreitz, Jesse M, Przychodzen, Bartlomiej, McConkey, Marie, Cowley, Glenn S, Doench, John G, Maciejewski, Jaroslaw P, Ebert, Benjamin L, Root, David E, Sankaran, Vijay G
Publicado no eLife (2019)

Lineage Tracing In Humans Enabled By Mitochondrial Mutations And Single Cell Genomics

Por Ludwig, Leif S., Lareau, Caleb A., Ulirsch, Jacob C., Christian, Elena, Muus, Christoph, Li, Lauren H., Pelka, Karin, Ge, Will, Oren, Yaara, Brack, Alison, Law, Travis, Rodman, Christopher, Chen, Jonathan H., Boland, Genevieve M., Hacohen, Nir, Rozenblatt-Rosen, Orit, Aryee, Martin J., Buenrostro, Jason D., Regev, Aviv, Sankaran, Vijay G.
Publicado no Cell (2019)

Massively parallel single-cell mitochondrial DNA genotyping and chromatin profiling

Por Lareau, Caleb A., Ludwig, Leif S., Muus, Christoph, Gohil, Satyen H., Zhao, Tongtong, Chiang, Zachary, Pelka, Karin, Verboon, Jeffrey M., Luo, Wendy, Christian, Elena, Rosebrock, Daniel, Getz, Gad, Boland, Genevieve M., Chen, Fei, Buenrostro, Jason D., Hacohen, Nir, Wu, Catherine J., Aryee, Martin J., Regev, Aviv, Sankaran, Vijay G.
Publicado no Nat Biotechnol (2020)

Impaired human hematopoiesis due to a cryptic intronic GATA1 splicing mutation

Por Abdulhay, Nour J., Fiorini, Claudia, Verboon, Jeffrey M., Ludwig, Leif S., Ulirsch, Jacob C., Zieger, Barbara, Lareau, Caleb A., Mi, Xiaoli, Roy, Anindita, Obeng, Esther A., Erlacher, Miriam, Gupta, Namrata, Gabriel, Stacey B., Ebert, Benjamin L., Niemeyer, Charlotte M., Khoriaty, Rami N., Ancliff, Philip, Gazda, Hanna T., Wlodarski, Marcin W., Sankaran, Vijay G.
Publicado no J Exp Med (2019)

Familial thrombocytopenia due to a complex structural variant resulting in a WAC-ANKRD26 fusion transcript

Por Wahlster, Lara, Verboon, Jeffrey M., Ludwig, Leif S., Black, Susan C., Luo, Wendy, Garg, Kopal, Voit, Richard A., Collins, Ryan L., Garimella, Kiran, Costello, Maura, Chao, Katherine R., Goodrich, Julia K., DiTroia, Stephanie P., O’Donnell-Luria, Anne, Talkowski, Michael E., Michelson, Alan D., Cantor, Alan B., Sankaran, Vijay G.
Publicado no J Exp Med (2021)

Targeted Application of Human Genetic Variation Can Improve Red Blood Cell Production from Stem Cells

Por Giani, Felix C., Fiorini, Claudia, Wakabayashi, Aoi, Ludwig, Leif S., Salem, Rany M., Jobaliya, Chintan D., Regan, Stephanie N., Ulirsch, Jacob C., Liang, Ge, Steinberg-Shemer, Orna, Guo, Michael H., Esko, Tõnu, Tong, Wei, Brugnara, Carlo, Hirschhorn, Joel N., Weiss, Mitchell J., Zon, Leonard I., Chou, Stella T., French, Deborah L., Musunuru, Kiran, Sankaran, Vijay G.
Publicado no Cell Stem Cell (2015)