Cyclin D3 coordinates the cell cycle during differentiation to regulate erythrocyte size and number

Genome-wide association studies (GWASs) have identified a genetic variant of moderate effect size at 6p21.1 associated with erythrocyte traits in humans. We show that this variant affects an erythroid-specific enhancer of CCND3. A Ccnd3 knockout mouse phenocopies these erythroid phenotypes, with a d...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Sankaran, Vijay G., Ludwig, Leif S., Sicinska, Ewa, Xu, Jian, Bauer, Daniel E., Eng, Jennifer C., Patterson, Heide Christine, Metcalf, Ryan A., Natkunam, Yasodha, Orkin, Stuart H., Sicinski, Piotr, Lander, Eric S., Lodish, Harvey F.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Cold Spring Harbor Laboratory Press 2012
Pynciau:
Research Paper
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3444733/
https://ncbi.nlm.nih.gov/pubmed/22929040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.197020.112
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