Gene-centric functional dissection of human genetic variation uncovers regulators of hematopoiesis

Genome-wide association studies (GWAS) have identified thousands of variants associated with human diseases and traits. However, the majority of GWAS-implicated variants are in non-coding regions of the genome and require in depth follow-up to identify target genes and decipher biological mechanisms...

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Bibliografiske detaljer
Udgivet i:eLife
Main Authors: Nandakumar, Satish K, McFarland, Sean K, Mateyka, Laura M, Lareau, Caleb A, Ulirsch, Jacob C, Ludwig, Leif S, Agarwal, Gaurav, Engreitz, Jesse M, Przychodzen, Bartlomiej, McConkey, Marie, Cowley, Glenn S, Doench, John G, Maciejewski, Jaroslaw P, Ebert, Benjamin L, Root, David E, Sankaran, Vijay G
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2019
Fag:
Genetics and Genomics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6534380/
https://ncbi.nlm.nih.gov/pubmed/31070582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.44080
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