Gene-centric functional dissection of human genetic variation uncovers regulators of hematopoiesis

Genome-wide association studies (GWAS) have identified thousands of variants associated with human diseases and traits. However, the majority of GWAS-implicated variants are in non-coding regions of the genome and require in depth follow-up to identify target genes and decipher biological mechanisms...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Nandakumar, Satish K, McFarland, Sean K, Mateyka, Laura M, Lareau, Caleb A, Ulirsch, Jacob C, Ludwig, Leif S, Agarwal, Gaurav, Engreitz, Jesse M, Przychodzen, Bartlomiej, McConkey, Marie, Cowley, Glenn S, Doench, John G, Maciejewski, Jaroslaw P, Ebert, Benjamin L, Root, David E, Sankaran, Vijay G
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2019
Assuntos:
Genetics and Genomics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6534380/
https://ncbi.nlm.nih.gov/pubmed/31070582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.44080
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