Gene-centric functional dissection of human genetic variation uncovers regulators of hematopoiesis

Genome-wide association studies (GWAS) have identified thousands of variants associated with human diseases and traits. However, the majority of GWAS-implicated variants are in non-coding regions of the genome and require in depth follow-up to identify target genes and decipher biological mechanisms...

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發表在:eLife
Main Authors: Nandakumar, Satish K, McFarland, Sean K, Mateyka, Laura M, Lareau, Caleb A, Ulirsch, Jacob C, Ludwig, Leif S, Agarwal, Gaurav, Engreitz, Jesse M, Przychodzen, Bartlomiej, McConkey, Marie, Cowley, Glenn S, Doench, John G, Maciejewski, Jaroslaw P, Ebert, Benjamin L, Root, David E, Sankaran, Vijay G
格式: Artigo
語言:Inglês
出版: eLife Sciences Publications, Ltd 2019
主題:
Genetics and Genomics
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6534380/
https://ncbi.nlm.nih.gov/pubmed/31070582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.44080
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