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Purifying Selection against Pathogenic Mitochondrial DNA in Human T Cells
Many mitochondrial diseases are caused by mutations in mitochondrial DNA (mtDNA). Patients’ cells contain a mixture of mutant and nonmutant mtDNA (a phenomenon called heteroplasmy). The proportion of mutant mtDNA varies across patients and among tissues within a patient. We simultaneously assayed si...
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| I publikationen: | N Engl J Med |
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| Huvudupphovsmän: | , , , , , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
2020
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7593775/ https://ncbi.nlm.nih.gov/pubmed/32786181 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa2001265 |
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