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Purifying Selection against Pathogenic Mitochondrial DNA in Human T Cells
Many mitochondrial diseases are caused by mutations in mitochondrial DNA (mtDNA). Patients’ cells contain a mixture of mutant and nonmutant mtDNA (a phenomenon called heteroplasmy). The proportion of mutant mtDNA varies across patients and among tissues within a patient. We simultaneously assayed si...
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| Publicado no: | N Engl J Med |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7593775/ https://ncbi.nlm.nih.gov/pubmed/32786181 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa2001265 |
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