Lineage Tracing In Humans Enabled By Mitochondrial Mutations And Single Cell Genomics

Lineage tracing provides key insights into the fate of individual cells in complex organisms. While effective genetic labeling approaches are available in model systems, in intact humans most approaches require detection of nuclear somatic mutations, which have high error rates, limited scale, and d...

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Gepubliceerd in:Cell
Hoofdauteurs: Ludwig, Leif S., Lareau, Caleb A., Ulirsch, Jacob C., Christian, Elena, Muus, Christoph, Li, Lauren H., Pelka, Karin, Ge, Will, Oren, Yaara, Brack, Alison, Law, Travis, Rodman, Christopher, Chen, Jonathan H., Boland, Genevieve M., Hacohen, Nir, Rozenblatt-Rosen, Orit, Aryee, Martin J., Buenrostro, Jason D., Regev, Aviv, Sankaran, Vijay G.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6408267/
https://ncbi.nlm.nih.gov/pubmed/30827679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2019.01.022
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