Lineage Tracing In Humans Enabled By Mitochondrial Mutations And Single Cell Genomics

Lineage tracing provides key insights into the fate of individual cells in complex organisms. While effective genetic labeling approaches are available in model systems, in intact humans most approaches require detection of nuclear somatic mutations, which have high error rates, limited scale, and d...

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Detalhes bibliográficos
Publicado no:Cell
Main Authors: Ludwig, Leif S., Lareau, Caleb A., Ulirsch, Jacob C., Christian, Elena, Muus, Christoph, Li, Lauren H., Pelka, Karin, Ge, Will, Oren, Yaara, Brack, Alison, Law, Travis, Rodman, Christopher, Chen, Jonathan H., Boland, Genevieve M., Hacohen, Nir, Rozenblatt-Rosen, Orit, Aryee, Martin J., Buenrostro, Jason D., Regev, Aviv, Sankaran, Vijay G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6408267/
https://ncbi.nlm.nih.gov/pubmed/30827679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2019.01.022
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