Altered translation of GATA1 in Diamond-Blackfan anemia

Ribosomal protein haploinsufficiency occurs in diverse human diseases including Diamond-Blackfan anemia (DBA),(1,2) congenital asplenia,(3) and T-cell leukemia.(4) Yet how mutations in such ubiquitously expressed proteins result in cell-type and tissue specific defects remains a mystery.(5) Here, we...

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Bibliografische gegevens
Hoofdauteurs: Ludwig, Leif S., Gazda, Hanna T., Eng, Jennifer C., Eichhorn, Stephen W., Thiru, Prathapan, Ghazvinian, Roxanne, George, Tracy I., Gotlib, Jason R., Beggs, Alan H., Sieff, Colin A., Lodish, Harvey F., Lander, Eric S., Sankaran, Vijay G.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2014
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4087046/
https://ncbi.nlm.nih.gov/pubmed/24952648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3557
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