Lipidated α/α-AA heterogeneous peptides as antimicrobial agents

Por Singh, Sylvia, Nimmagadda, Alekhya, Su, Ma, Wang, Minghui, Teng, Peng, Cai, Jianfeng
Publicado no Eur J Med Chem (2018)

Preparation and evaluation of tetrabenazine enantiomers and all eight stereoisomers of dihydrotetrabenazine as VMAT2 inhibitors

Por Yao, Zhangyu, Wei, Xueying, Wu, Xiaoming, Katz, Jonathan L., Kopajtic, Theresa, Greig, Nigel H., Sun, Hongbin
Publicado no Eur J Med Chem (2011)

N,N′-Diaryl-Bishydrazones in a Biphenyl Platform: Broad Spectrum Antifungal Agents

Por Chandrika, Nishad Thamban, Dennis, Emily K., Shrestha, Sanjib K., Ngo, Huy X., Green, Keith D., Kwiatkowski, Stefan, Deaciuc, Agripina Gabriela, Dwoskin, Linda P., Watt, David S., Garneau-Tsodikova, Sylvie
Publicado no Eur J Med Chem (2018)

Exploration of DAPI analogues: Synthesis, antitrypanosomal activity, DNA binding and fluorescence properties

Por Farahat, Abdelbasset A., Kumar, Arvind, Say, Martial, Wenzler, Tanja, Brun, Reto, Paul, Ananya, Wilson, W. David, Boykin, David W.
Publicado no Eur J Med Chem (2017)

Synthesis, Optimization and Structure-Activity Relationships of 3,5-Disubstituted Isoxazolines as New Anti-tuberculosis Agents

Por Rakesh, Dianqing Sun, Lee, Robin B., Tangallapally, Rajendra, Lee, Richard E.
Publicado em 2008

Synthesis of alkenyldiarylmethanes (ADAMs) containing benzo[d]isoxazole and oxazolidin-2-one rings, a new series of potent non-nucleoside HIV-1 reverse transcriptase inhibitors

Por Deng, Bo-Liang, Zhao, Yujie, Hartman, Tracy L., Watson, Karen, Buckheit, Robert W., Pannecouque, Christophe, De Clercq, Erik, Cushman, Mark
Publicado em 2008

Selective and potent agonists for estrogen receptor beta derived from molecular refinements of salicylaldoximes

Por Bertini, Simone, De Cupertinis, Andrea, Granchi, Carlotta, Bargagli, Barbara, Tuccinardi, Tiziano, Martinelli, Adriano, Macchia, Marco, Gunther, Jillian R., Carlson, Kathryn E., Katzenellenbogen, John A., Minutolo, Filippo
Publicado em 2011

Synthesis, antiproliferative activity, and mechanism of action of a series of 2-{[(2E)-3-phenylprop-2-enoyl]amino}benzamides

Por Raffa, Demetrio, Maggio, Benedetta, Plescia, Fabiana, Cascioferro, Stella, Plescia, Salvatore, Raimondi, Maria Valeria, Daidone, Giuseppe, Tolomeo, Manlio, Grimaudo, Stefania, Di Cristina, Antonietta, Pipitone, Rosaria Maria, Bai, Ruoli, Hamel, Ernest
Publicado em 2011

Synthesis and characterization of novel bis(carboxylato)dichloridobis(ethylamine)platinum(IV) complexes with higher cytotoxicity than cisplatin

Por Varbanov, Hristo, Valiahdi, Seied M., Legin, Anton A., Jakupec, Michael A., Roller, Alexander, Galanski, Mathea S., Keppler, Bernhard K.
Publicado em 2011

Analogs of Pentamidine as Potential Anti-Pneumocystis Chemotherapeutics

Por Maciejewska, Dorota, Żabinski, Jerzy, Kaźmierczak, Pawel, Rezler, Mateusz, Krassowska-Świebocka, Barbara, Collins, Margaret S., Cushion, Melanie T.
Publicado em 2011

Design, synthesis and antiproliferative activity of some 3-benzylidene-2,3-dihydro-1-benzopyran-4-ones which display selective toxicity for malignant cells

Por Perjési, Pal, Das, Umashankar, De Clercq, Erik, Balzarini, Jan, Kawase, Masame, Sakagami, Hiroshi, Stables, James P., Lorand, Tamas, Rozmer, Zsuzsanna, Dimmock, Jonathan R.
Publicado em 2007

Inhibition of Hepatitis C Virus NS5B Polymerase by S-Trityl-L-Cysteine Derivatives

Por Nichols, Daniel B., Fournet, Guy, Gurukumar, K. R., Basu, Amartya, Lee, Jin-Ching, Sakamoto, Naoya, Kozielski, Frank, Musmuca, Ira, Joseph, Benoît, Ragno, Rino, Kaushik-Basu, Neerja
Publicado em 2012

Synthesis and Biological Evaluation in U87MG Glioma Cells of (Ethynylthiophene)Sulfonamido-Based Hydroxamates as Matrix Metalloproteinase Inhibitors

Por Nuti, Elisa, Casalini, Francesca, Santamaria, Salvatore, Gabelloni, Pamela, Bendinelli, Sara, Da Pozzo, Eleonora, Costa, Barbara, Marinelli, Luciana, La Pietra, Valeria, Novellino, Ettore, Bernardo, M. Margarida, Fridman, Rafael, Da Settimo, Federico, Martini, Claudia, Rossello, Armando
Publicado em 2011

The synthesis of 2,5-Bis(4-amidinophenyl)thiophene derivatives providing submicromolar-range inhibition of the botulinum neurotoxin serotype A metalloprotease

Por Opsenica, Igor, Filipovic, Vuk, Nuss, Jon E., Gomba, Laura M., Opsenica, Dejan, Burnett, James C., Gussio, Rick, Solaja, Bogdan A., Bavari, Sina
Publicado em 2012

Synthesis, DNA binding and antileishmanial activity of low molecular weight bis-arylimidamides

Por Banerjee, Moloy, Farahat, Abdelbasset A., Kumar, Arvind, Wenzler, Tanja, Brun, Reto, Munde, Manoj M., Wilson, W. David, Zhu, Xiaohua, Werbovetz, Karl A., Boykin, David W.
Publicado em 2012

Synthesis of Quinoline Derivatives: Discovery of a Potent and Selective Phosphodiesterase 5 Inhibitor for the Treatment of Alzheimer's disease

Por Fiorito, Jole, Saeed, Faisal, Zhang, Hong, Staniszewski, Agnieszka, Feng, Yan, Francis, Yitshak I., Rao, Sudha, Thakkar, Devarshi M., Deng, Shi-Xian, Landry, Donald W., Arancio, Ottavio
Publicado em 2012

UNC1062, a new and potent Mer inhibitor

Por Liu, Jing, Zhang, Weihe, Stashko, Michael A, DeRyckere, Deborah, Cummings, Christopher T., Hunter, Debra, Yang, Chao, Jayakody, Chatura N., Cheng, Nancy, Simpson, Catherine, Norris-Drouin, Jacqueline, Sather, Susan, Kireev, Dmitri, Janzen, William P., Earp, H Shelton, Graham, Douglas K., Frye, Stephen V., Wang, Xiaodong
Publicado em 2013

Probes for narcotic receptor mediated phenomena. 48. C7- and C8-Substituted 5-phenylmorphan opioids from diastereoselective alkylation

Por Lim, Hwan Jung, Dersch, Christina M., Rothman, Richard B., Deschamps, Jeffrey R., Jacobson, Arthur E., Rice, Kenner C.
Publicado em 2013

Practical synthesis of a chromene analog for use as a retinoic acid receptor alpha antagonist lead compound

Por Jetson, Rachael, Malik, Neha, Luniwal, Amarjit, Chari, Venkatesh, Ratnam, Manohar, Erhardt, Paul
Publicado em 2013

Structure-Activity Relationship (SAR) and Preliminary Mode of Action Studies of 3-Substituted Benzylthioquinolinium Iodide as Anti-opportunistic Infection Agents

Por Bolden, Sidney, Zhu, Xue Y., Etukala, Jagan R, Boateng, Comfort, Mazu, Tryphon, Flores-Rozas, Hernan, Jacob, Melissa R., Khan, Shabana I, Walker, Larry A., Ablordeppey, Seth Y.
Publicado em 2013