2-Heteroarylimino-5-arylidene-4-thiazolidinones as a new class of non-nucleoside inhibitors of HCV NS5B polymerase

Por Küçükgüzel, İlkay, Satilmiş, Gökhan, Gurukumar, K.R., Basu, Amartya, Tatar, Esra, Nichols, Daniel B., Talele, Tanaji T., Kaushik-Basu, Neerja
Publicado em 2013

Expanding Chemical Diversity of Conotoxins: Peptoid-Peptide Chimeras of the Sodium Channel Blocker µ-KIIIA and its Selenopeptide Analogues

Por Walewska, Aleksandra, Han, Tiffany S., Zhang, Min-Min, Yoshikami, Doju, Bulaj, Grzegorz, Rolka, Krzysztof
Publicado no Eur J Med Chem (2013)

Synthesis and structure activity relationship studies of novel Staphylococcus aureus Sortase A inhibitors

Por Chenna, Bala Chandra, King, Jason R., Shinkre, Bidhan A., Glover, Amanda L., Lucius, Aaron L., Velu, Sadanandan E.
Publicado no Eur J Med Chem (2010)

Probes for narcotic receptor mediated phenomena 49. N-Substituted rac-cis-4a-arylalkyl-1,2,3,4,4a,9a-hexahydrobenzofuro[2,3-c]pyridin-6-ols

Por Iyer, Malliga R., Rothman, Richard B., Dersch, Christina M., Jacobson, Arthur E., Rice, Kenner C.
Publicado no Eur J Med Chem (2015)

Structure-Based Inhibition of Protein-Protein Interactions

Por Watkins, Andrew M., Arora, Paramjit S.
Publicado no Eur J Med Chem (2014)

Identification of human presequence protease (hPreP) agonists for the treatment of Alzheimer’s disease

Por Vangavaragu, Jhansi Rani, Valasani, Koteswara Rao, Gan, Xueqi, Yan, Shirley ShiDu
Publicado no Eur J Med Chem (2014)

Metronidazole-triazole conjugates: Activity against Clostridium difficile and parasites

Por Jarrad, Angie M., Karoli, Tomislav, Debnath, Anjan, Tay, Chin Yen, Huang, Johnny X., Kaeslin, Geraldine, Elliott, Alysha G., Miyamoto, Yukiko, Ramu, Soumya, Kavanagh, Angela M., Zuegg, Johannes, Eckmann, Lars, Blaskovich, Mark A.T., Cooper, Matthew A.
Publicado no Eur J Med Chem (2015)

Synthesis and biological evaluation of 6-substituted indolizinoquinolinediones as catalytic DNA topoisomerase I inhibitors

Por Yu, Le-Mao, Zhang, Xiao-Ru, Li, Xiao-Bing, Yang, Yuan, Wei, Hong-Yu, He, Xi-Xin, Gu, Lian-Quan, Huang, Zhi-Shu, Pommier, Yves, An, Lin-Kun
Publicado no Eur J Med Chem (2015)

Probing the Structural Requirements of Non-electrophilic Naphthalene-Based Nrf2 Activators

Por Jain, Atul D., Potteti, Haranatha, Richardson, Benjamin G., Kingsley, Laura, Luciano, Julia P., Ryuzoji, Aya F., Lee, Hyun, Krunic, Aleksej, Mesecar, Andrew D., Reddy, Sekhar P., Moore, Terry W.
Publicado no Eur J Med Chem (2015)

Identification of novel cyclic lipopeptides from a positional scanning combinatorial library with enhanced antibacterial and antibiofilm activities

Por Bionda, Nina, Fleeman, Renee M., de la Fuente-Núñez, César, Rodriguez, Maria C., Reffuveille, Fany, Shaw, Lindsey N., Pastar, Irena, Davis, Stephen C., Hancock, Robert E. W., Cudic, Predrag
Publicado no Eur J Med Chem (2015)

A structural insight into the P1-S1 binding mode of diaminoethylphosphonic and phosphinic acids, selective inhibitors of alanine aminopeptidases

Por Węglarz-Tomczak, Ewelina, Berlicki, Łukasz, Pawełczak, Małgorzata, Nocek, Bogusław, Joachimiak, Andrzej, Mucha, Artur
Publicado no Eur J Med Chem (2016)

Antitrypanosomal activity of 5-nitro-2-aminothiazole-based compounds

Por Papadopoulou, Maria V., Bloomer, William D., Rosenzweig, Howard S., Wilkinson, Shane R., Szular, Joanna, Kaiser, Marcel
Publicado no Eur J Med Chem (2016)

Synthesis, molecular modeling and biological evaluation of novel tadalafil analogues as phosphodiesterase 5 and colon tumor cell growth inhibitors, new stereochemical perspective

Por Abadi, Ashraf H., Gary, Bernard D., Tinsley, Heather N., Piazza, Gary A., Abdel-Halim, Mohammad
Publicado no Eur J Med Chem (2010)

A Structure-Activity Relationship Study of ABCC2 Inhibitors

Por Wissel, Gloria, Deng, Feng, Kudryavtsev, Pavel, Ghemtio, Leo, Wipf, Peter, Xhaard, Henri, Kidron, Heidi
Publicado no Eur J Pharm Sci (2017)

Substituted arylsulphonamides as inhibitors of perforin-mediated lysis

Por Spicer, Julie A., Miller, Christian K., O'Connor, Patrick D., Jose, Jiney, Huttunen, Kristiina M., Jaiswal, Jagdish K., Denny, William A., Akhlaghi, Hedieh, Browne, Kylie A., Trapani, Joseph A.
Publicado no Eur J Med Chem (2017)

Multifunctional Thiosemicarbazones and Deconstructed Analogues as a Strategy to Study the Involvement of Metal Chelation, Sigma-2 (σ(2)) Receptor and P-gp Protein in the Cytotoxic...

Por Pati, Maria Laura, Niso, Mauro, Spitzer, Dirk, Berardi, Francesco, Contino, Marialessandra, Riganti, Chiara, Hawkins, William G, Abate, Carmen
Publicado no Eur J Med Chem (2017)

Discovery of a Potent Dual ALK and EGFR T790M Inhibitor

Por Jang, Jaebong, Son, Jung Beom, To, Ciric, Bahcall, Magda, Kim, So Young, Kang, Seock Yong, Mushajiang, Mierzhati, Lee, Younho, Jänne, Pasi A., Choi, Hwan Geun, Gray, Nathanael S.
Publicado no Eur J Med Chem (2017)

Development of Inhibitors of Receptor Protein Tyrosine Phosphatase β/ζ (PTPRZ1) as Candidates for CNS disorders

Por Pastor, Miryam, Fernández-Calle, Rosalía, Di Geronimo, Bruno, Vicente-Rodríguez, Marta, Zapico, José María, Gramage, Esther, Coderch, Claire, Pérez-García, Carmen, Lasek, Amy W., Puchades-Carrasco, Leonor, Pineda-Lucena, Antonio, de Pascual-Teresa, Beatriz, Herradón, Gonzalo, Ramos, Ana
Publicado no Eur J Med Chem (2017)

Anti-inflammatory hybrids of secondary amines and amide-sulfamide derivatives

Por Bai, Renren, Sun, Jian, Liang, Zhongxing, Yoon, Younghyoun, Salgado, Eric, Feng, Amber, Oum, Yoonhyeun, Xie, Yuanyuan, Shim, Hyunsuk
Publicado no Eur J Med Chem (2018)

Discovery of Potent and Selective BRD4 Inhibitors Capable of Blocking TLR3-Induced Acute Airway Inflammation

Por Liu, Zhiqing, Tian, Bing, Chen, Haiying, Wang, Pingyuan, Brasier, Allan R., Zhou, Jia
Publicado no Eur J Med Chem (2018)