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Expanding Chemical Diversity of Conotoxins: Peptoid-Peptide Chimeras of the Sodium Channel Blocker µ-KIIIA and its Selenopeptide Analogues

The µ-conotoxin KIIIA is a three disulfide-bridged blocker of voltage-gated sodium channels (VGSCs). The Lys(7) residue in KIIIA is an attractive target for manipulating the selectivity and efficacy of this peptide. Here, we report the design and chemical synthesis of µ-conopeptoid analogues (peptom...

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Detalhes bibliográficos
Publicado no:Eur J Med Chem
Main Authors: Walewska, Aleksandra, Han, Tiffany S., Zhang, Min-Min, Yoshikami, Doju, Bulaj, Grzegorz, Rolka, Krzysztof
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4332556/
https://ncbi.nlm.nih.gov/pubmed/23707919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2013.04.041
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