Expanding Chemical Diversity of Conotoxins: Peptoid-Peptide Chimeras of the Sodium Channel Blocker µ-KIIIA and its Selenopeptide Analogues

The µ-conotoxin KIIIA is a three disulfide-bridged blocker of voltage-gated sodium channels (VGSCs). The Lys(7) residue in KIIIA is an attractive target for manipulating the selectivity and efficacy of this peptide. Here, we report the design and chemical synthesis of µ-conopeptoid analogues (peptom...

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Bibliographic Details
Published in:Eur J Med Chem
Main Authors: Walewska, Aleksandra, Han, Tiffany S., Zhang, Min-Min, Yoshikami, Doju, Bulaj, Grzegorz, Rolka, Krzysztof
Format: Artigo
Language:Inglês
Published: 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4332556/
https://ncbi.nlm.nih.gov/pubmed/23707919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2013.04.041
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