Cooccupancy of the Outer Vestibule of Voltage-Gated Sodium Channels by μ-Conotoxin KIIIA and Saxitoxin or Tetrodotoxin

The guanidinium alkaloids tetrodotoxin (TTX) and saxitoxin (STX) are classic ligands of voltage-gated sodium channels (VGSCs). Like TTX and STX, μ-conotoxin peptides are pore blockers but with greater VGSC subtype selectivity. μ-Conotoxin KIIIA blocks the neuronal subtype Na(V)1.2 with nanomolar aff...

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Detalhes bibliográficos
Main Authors: Zhang, Min-Min, Gruszczynski, Pawel, Walewska, Aleksandra, Bulaj, Grzegorz, Olivera, Baldomero M., Yoshikami, Doju
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2010
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2904204/
https://ncbi.nlm.nih.gov/pubmed/20410356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/jn.00145.2010
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