Synergistic and Antagonistic Interactions between Tetrodotoxin and μ-Conotoxin in Blocking Voltage-gated Sodium Channels

Tetrodotoxin (TTX) is the quintessential ligand of voltage-gated sodium channels (Na(V)s). Like TTX, μ-conotoxin peptides are pore blockers, and both toxins have helped to define the properties of neurotoxin receptor Site 1 of Na(V)s. Here, we report unexpected results showing that the recently disc...

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Bibliographic Details
Main Authors: Zhang, Min-Min, McArthur, Jeff R., Azam, Layla, Bulaj, Grzegorz, Olivera, Baldomero M, French, Robert J, Yoshikami, Doju
Format: Artigo
Language:Inglês
Published: 2009
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2878737/
https://ncbi.nlm.nih.gov/pubmed/19221510
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