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Co-expression of Na(V)β subunits alters the kinetics of inhibition of voltage-gated sodium channels by pore-blocking μ-conotoxins
BACKGROUND AND PURPOSE: Voltage-gated sodium channels (VGSCs) are assembled from two classes of subunits, a pore-bearing α-subunit (Na(V)1) and one or two accessory β-subunits (Na(V)βs). Neurons in mammals can express one or more of seven isoforms of Na(V)1 and one or more of four isoforms of Na(V)β...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Publishing Ltd
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3605869/ https://ncbi.nlm.nih.gov/pubmed/23146020 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12051 |
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