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Na(V)β Subunits Modulate the Inhibition of Na(V)1.8 by the Analgesic Gating Modifier μO-Conotoxin MrVIB
Voltage-gated sodium channels (VGSCs) consist of a pore-forming α-subunit and regulatory β-subunits. Several families of neuroactive peptides of Conus snails target VGSCs, including μO-conotoxins and μ-conotoxins. Unlike μ-conotoxins and the guanidinium alkaloid saxitoxin (STX), which are pore block...
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| Principais autores: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Pharmacology and Experimental Therapeutics
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3141899/ https://ncbi.nlm.nih.gov/pubmed/21586605 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.110.178343 |
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