Specificity, affinity and efficacy of iota-conotoxin RXIA, an agonist of voltage-gated sodium channels Na(V)1.2, 1.6 and 1.7

The excitotoxic conopeptide ι-RXIA induces repetitive action potentials in frog motor axons and seizures upon intracranial injection into mice. We recently discovered that ι-RXIA shifts the voltage-dependence of activation of voltage-gated sodium channel Na(V)1.6 to a more hyperpolarized level. Here...

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Main Authors: Fiedler, Brian, Zhang, Min-Min, Buczek, Oga, Azam, Layla, Bulaj, Grzegorz, Norton, Raymond S, Olivera, Baldomero M, Yoshikami, Doju
Formato: Artigo
Idioma:Inglês
Publicado: 2008
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2700742/
https://ncbi.nlm.nih.gov/pubmed/18486102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2008.03.019
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