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µ-Conotoxin KIIIA Derivatives with Divergent Affinities versus Efficacies in Blocking Voltage-gated Sodium Channels
The possibility of independently manipulating the affinity and efficacy of pore-blocking ligands of sodium channels is of interest for the development of new drugs for the treatment of pain. The analgesic µ-conotoxin KIIIA, a 16-residue peptide with three disulfide bridges, is a pore-blocker of volt...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2907105/ https://ncbi.nlm.nih.gov/pubmed/20459109 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi100207k |
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