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µ-Conotoxin KIIIA Derivatives with Divergent Affinities versus Efficacies in Blocking Voltage-gated Sodium Channels

The possibility of independently manipulating the affinity and efficacy of pore-blocking ligands of sodium channels is of interest for the development of new drugs for the treatment of pain. The analgesic µ-conotoxin KIIIA, a 16-residue peptide with three disulfide bridges, is a pore-blocker of volt...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Zhang, Min-Min, Han, Tiffany S., Olivera, Baldomero M., Bulaj, Grzegorz, Yoshikami, Doju
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2907105/
https://ncbi.nlm.nih.gov/pubmed/20459109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi100207k
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