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Na(V)β Subunits Modulate the Inhibition of Na(V)1.8 by the Analgesic Gating Modifier μO-Conotoxin MrVIB

Voltage-gated sodium channels (VGSCs) consist of a pore-forming α-subunit and regulatory β-subunits. Several families of neuroactive peptides of Conus snails target VGSCs, including μO-conotoxins and μ-conotoxins. Unlike μ-conotoxins and the guanidinium alkaloid saxitoxin (STX), which are pore block...

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Bibliografiske detaljer
Main Authors: Wilson, Michael J., Zhang, Min-Min, Azam, Layla, Olivera, Baldomero M., Bulaj, Grzegorz, Yoshikami, Doju
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Pharmacology and Experimental Therapeutics 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3141899/
https://ncbi.nlm.nih.gov/pubmed/21586605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.110.178343
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