Co-expression of Na(V)β subunits alters the kinetics of inhibition of voltage-gated sodium channels by pore-blocking μ-conotoxins

BACKGROUND AND PURPOSE: Voltage-gated sodium channels (VGSCs) are assembled from two classes of subunits, a pore-bearing α-subunit (Na(V)1) and one or two accessory β-subunits (Na(V)βs). Neurons in mammals can express one or more of seven isoforms of Na(V)1 and one or more of four isoforms of Na(V)β...

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Bibliographic Details
Main Authors: Zhang, Min-Min, Wilson, Michael J, Azam, Layla, Gajewiak, Joanna, Rivier, Jean E, Bulaj, Grzegorz, Olivera, Baldomero M, Yoshikami, Doju
Format: Artigo
Language:Inglês
Published: Blackwell Publishing Ltd 2013
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Research Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3605869/
https://ncbi.nlm.nih.gov/pubmed/23146020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12051
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