The Tetrodotoxin Receptor of Voltage-Gated Sodium Channels—Perspectives from Interactions with μ-Conotoxins

Neurotoxin receptor site 1, in the outer vestibule of the conducting pore of voltage-gated sodium channels (VGSCs), was first functionally defined by its ability to bind the guanidinium-containing agents, tetrodotoxin (TTX) and saxitoxin (STX). Subsequent studies showed that peptide μ-conotoxins com...

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Detalles Bibliográficos
Main Authors: French, Robert J., Yoshikami, Doju, Sheets, Michael F., Olivera, Baldomero M.
Formato: Artigo
Idioma:Inglês
Publicado: Molecular Diversity Preservation International 2010
Assuntos:
Review
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2920548/
https://ncbi.nlm.nih.gov/pubmed/20714429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md8072153
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