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Structure of the analgesic μ-conotoxin KIIIA and effects on structure and function of disulfide deletion(,)
The μ-conotoxin μ-KIIIA, from Conus kinoshitai, blocks mammalian neuronal voltage-gated sodium channels (VGSCs) and is a potent analgesic following systemic administration in mice. We have determined its solution structure using NMR spectroscopy. Key residues identified previously as being important...
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| Главные авторы: | , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2009
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4153535/ https://ncbi.nlm.nih.gov/pubmed/19170536 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi801998a |
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