Structure of the analgesic μ-conotoxin KIIIA and effects on structure and function of disulfide deletion(,)

The μ-conotoxin μ-KIIIA, from Conus kinoshitai, blocks mammalian neuronal voltage-gated sodium channels (VGSCs) and is a potent analgesic following systemic administration in mice. We have determined its solution structure using NMR spectroscopy. Key residues identified previously as being important...

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Main Authors: Khoo, Keith K., Feng, Zhi-Ping, Smith, Brian J., Zhang, Min-Min, Yoshikami, Doju, Olivera, Baldomero M., Bulaj, Grzegorz, Norton, Raymond S.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4153535/
https://ncbi.nlm.nih.gov/pubmed/19170536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi801998a
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