Lactam-stabilized helical analogues of the analgesic μ-conotoxin KIIIA

μ-Conotoxin KIIIA (μ-KIIIA) blocks mammalian voltage-gated sodium channels (VGSCs) and is a potent analgesic following systemic administration in mice. Previous structure-activity studies of μ-KIIIA identified a helical pharmacophore for VGSC blockade. This suggested a route for designing truncated...

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Detalhes bibliográficos
Main Authors: Khoo, Keith K., Wilson, Michael J., Smith, Brian J., Zhang, Min-Min, Gulyas, Joszef, Yoshikami, Doju, Rivier, Jean E., Bulaj, Grzegorz, Norton, Raymond S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3228837/
https://ncbi.nlm.nih.gov/pubmed/21962108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm200839a
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