Lactam-stabilized helical analogues of the analgesic μ-conotoxin KIIIA

μ-Conotoxin KIIIA (μ-KIIIA) blocks mammalian voltage-gated sodium channels (VGSCs) and is a potent analgesic following systemic administration in mice. Previous structure-activity studies of μ-KIIIA identified a helical pharmacophore for VGSC blockade. This suggested a route for designing truncated...

Full description

Saved in:
Bibliographic Details
Main Authors: Khoo, Keith K., Wilson, Michael J., Smith, Brian J., Zhang, Min-Min, Gulyas, Joszef, Yoshikami, Doju, Rivier, Jean E., Bulaj, Grzegorz, Norton, Raymond S.
Format: Artigo
Language:Inglês
Published: 2011
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3228837/
https://ncbi.nlm.nih.gov/pubmed/21962108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm200839a
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items