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Lactam-stabilized helical analogues of the analgesic μ-conotoxin KIIIA
μ-Conotoxin KIIIA (μ-KIIIA) blocks mammalian voltage-gated sodium channels (VGSCs) and is a potent analgesic following systemic administration in mice. Previous structure-activity studies of μ-KIIIA identified a helical pharmacophore for VGSC blockade. This suggested a route for designing truncated...
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| Main Authors: | , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3228837/ https://ncbi.nlm.nih.gov/pubmed/21962108 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm200839a |
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