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Structurally-Minimized μ-Conotoxin Analogs as Sodium Channel Blockers: Implications for Designing Conopeptide-Based Therapeutics
Disulfide bridges, which stabilize the native conformation of conotoxins impose a challenge in the synthesis of smaller analogs. In this work, we describe the synthesis of a minimized analog of the analgesic μ-conotoxin KIIIA that blocks two sodium channel subtypes, the neuronal Na(V)1.2 and skeleta...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4074532/ https://ncbi.nlm.nih.gov/pubmed/19107760 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.200800292 |
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