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Integrated Oxidative Folding of Cysteine/Selenocysteine Containing Peptides: Improving Chemical Synthesis of Conotoxins

Chemical synthesis of disulfide-rich peptides requires improvements in oxidative folding and disulfide mapping. To address these challenges, we combined the use of diselenide and selectively ((15)N/ (13)C)-labeled disulfide bridges. Conotoxin analogs, each with a pair of selenocysteines and labeled...

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Autors principals: Walewska, Aleksandra, Zhang, Min-Min, Skalicky, Jack J., Yoshikami, Doju, Olivera, Baldomero M., Bulaj, Grzegorz
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2919336/
https://ncbi.nlm.nih.gov/pubmed/19206132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.200806085
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