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Integrated Oxidative Folding of Cysteine/Selenocysteine Containing Peptides: Improving Chemical Synthesis of Conotoxins
Chemical synthesis of disulfide-rich peptides requires improvements in oxidative folding and disulfide mapping. To address these challenges, we combined the use of diselenide and selectively ((15)N/ (13)C)-labeled disulfide bridges. Conotoxin analogs, each with a pair of selenocysteines and labeled...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2919336/ https://ncbi.nlm.nih.gov/pubmed/19206132 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.200806085 |
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