NMR-Based Mapping of Disulfide Bridges in Cysteine-Rich Peptides: Application to the μ-Conotoxin SxIIIA

Disulfide-rich peptides represent a megadiverse group of natural products with very promising therapeutic potential. To accelerate their functional characterization, high-throughput chemical synthesis and folding methods are required, including efficient mapping of multiple disulfide bridges. Here,...

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Autores principales: Walewska, Aleksandra, Skalicky, Jack J., Davis, Darrell R., Zhang, Min-Min, Lopez-Vera, Estuardo, Watkins, Maren, Han, Tiffany S., Yoshikami, Doju, Olivera, Baldomero M., Bulaj, Grzegorz
Formato: Artigo
Lenguaje:Inglês
Publicado: 2008
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2665793/
https://ncbi.nlm.nih.gov/pubmed/18831583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja804303p
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