Structurally-Minimized μ-Conotoxin Analogs as Sodium Channel Blockers: Implications for Designing Conopeptide-Based Therapeutics

Disulfide bridges, which stabilize the native conformation of conotoxins impose a challenge in the synthesis of smaller analogs. In this work, we describe the synthesis of a minimized analog of the analgesic μ-conotoxin KIIIA that blocks two sodium channel subtypes, the neuronal Na(V)1.2 and skeleta...

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Autori principali: Han, Tiffany S., Zhang, Min-Min, Walewska, Aleksandra, Gruszczynski, Pawel, Robertson, Charles R., Cheatham, Thomas E., Yoshikami, Doju, Olivera, Baldomero M., Bulaj, Grzegorz
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4074532/
https://ncbi.nlm.nih.gov/pubmed/19107760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.200800292
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