Substituted arylsulphonamides as inhibitors of perforin-mediated lysis

The structure-activity relationships for a series of arylsulphonamide-based inhibitors of the pore-forming protein perforin have been explored. Perforin is a key component of the human immune response, however inappropriate activity has also been implicated in certain auto-immune and therapy-induced...

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Udgivet i:Eur J Med Chem
Main Authors: Spicer, Julie A., Miller, Christian K., O'Connor, Patrick D., Jose, Jiney, Huttunen, Kristiina M., Jaiswal, Jagdish K., Denny, William A., Akhlaghi, Hedieh, Browne, Kylie A., Trapani, Joseph A.
Format: Artigo
Sprog:Inglês
Udgivet: Editions Scientifiques Elsevier 2017
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5500991/
https://ncbi.nlm.nih.gov/pubmed/28582670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2017.05.048
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