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Regulation of perforin lysis: Implications for protein disulfide isomerase proteins
Perforin, a membrane-permeabilizing protein, is important to T cell cytotoxic action. Perforin has potential to damage the T cell in the endoplasmic reticulum (ER), is sequestered in granules, and later is exocytosed to kill cells. In the ER and after exocytosis, calcium and pH favor perforin activi...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2667449/ https://ncbi.nlm.nih.gov/pubmed/19147124 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellimm.2008.12.001 |
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