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Low dose IL-15 induces snap arming of CD44(low) T lymphocytes in the absence of antigen
It is widely accepted that naïve T cells require two signals, antigen recognition and co-simulation, to become cytotoxic over the course of 3–5 days. However, we observed that freshly isolated murine splenocytes without exposure to antigen become cytotoxic within 24 hours after culture with IL-15. I...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2613908/ https://ncbi.nlm.nih.gov/pubmed/18485336 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellimm.2008.04.007 |
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