Exploration of a Series of 5-Arylidene-2-thioxoimidazolidin-4-ones as Inhibitors of the Cytolytic Protein Perforin

[Image: see text] A series of novel 5-arylidene-2-thioxoimidazolidin-4-ones were investigated as inhibitors of the lymphocyte-expressed pore-forming protein perforin. Structure–activity relationships were explored through variation of an isoindolinone or 3,4-dihydroisoquinolinone subunit on a fixed...

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Detalhes bibliográficos
Main Authors: Spicer, Julie A., Lena, Gersande, Lyons, Dani M., Huttunen, Kristiina M., Miller, Christian K., O’Connor, Patrick D., Bull, Matthew, Helsby, Nuala, Jamieson, Stephen M. F., Denny, William A., Ciccone, Annette, Browne, Kylie A., Lopez, Jamie A., Rudd-Schmidt, Jesse, Voskoboinik, Ilia, Trapani, Joseph A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2013
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3865801/
https://ncbi.nlm.nih.gov/pubmed/24195776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm401604x
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