Exploration of a Series of 5-Arylidene-2-thioxoimidazolidin-4-ones as Inhibitors of the Cytolytic Protein Perforin

[Image: see text] A series of novel 5-arylidene-2-thioxoimidazolidin-4-ones were investigated as inhibitors of the lymphocyte-expressed pore-forming protein perforin. Structure–activity relationships were explored through variation of an isoindolinone or 3,4-dihydroisoquinolinone subunit on a fixed...

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Egile Nagusiak: Spicer, Julie A., Lena, Gersande, Lyons, Dani M., Huttunen, Kristiina M., Miller, Christian K., O’Connor, Patrick D., Bull, Matthew, Helsby, Nuala, Jamieson, Stephen M. F., Denny, William A., Ciccone, Annette, Browne, Kylie A., Lopez, Jamie A., Rudd-Schmidt, Jesse, Voskoboinik, Ilia, Trapani, Joseph A.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Chemical Society 2013
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3865801/
https://ncbi.nlm.nih.gov/pubmed/24195776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm401604x
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