Exploration of a Series of 5-Arylidene-2-thioxoimidazolidin-4-ones as Inhibitors of the Cytolytic Protein Perforin

[Image: see text] A series of novel 5-arylidene-2-thioxoimidazolidin-4-ones were investigated as inhibitors of the lymphocyte-expressed pore-forming protein perforin. Structure–activity relationships were explored through variation of an isoindolinone or 3,4-dihydroisoquinolinone subunit on a fixed...

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Autors principals: Spicer, Julie A., Lena, Gersande, Lyons, Dani M., Huttunen, Kristiina M., Miller, Christian K., O’Connor, Patrick D., Bull, Matthew, Helsby, Nuala, Jamieson, Stephen M. F., Denny, William A., Ciccone, Annette, Browne, Kylie A., Lopez, Jamie A., Rudd-Schmidt, Jesse, Voskoboinik, Ilia, Trapani, Joseph A.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2013
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3865801/
https://ncbi.nlm.nih.gov/pubmed/24195776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm401604x
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