Exploration of a Series of 5-Arylidene-2-thioxoimidazolidin-4-ones as Inhibitors of the Cytolytic Protein Perforin

[Image: see text] A series of novel 5-arylidene-2-thioxoimidazolidin-4-ones were investigated as inhibitors of the lymphocyte-expressed pore-forming protein perforin. Structure–activity relationships were explored through variation of an isoindolinone or 3,4-dihydroisoquinolinone subunit on a fixed...

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Bibliografski detalji
Glavni autori: Spicer, Julie A., Lena, Gersande, Lyons, Dani M., Huttunen, Kristiina M., Miller, Christian K., O’Connor, Patrick D., Bull, Matthew, Helsby, Nuala, Jamieson, Stephen M. F., Denny, William A., Ciccone, Annette, Browne, Kylie A., Lopez, Jamie A., Rudd-Schmidt, Jesse, Voskoboinik, Ilia, Trapani, Joseph A.
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2013
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3865801/
https://ncbi.nlm.nih.gov/pubmed/24195776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm401604x
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