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Perforinopathy: A Spectrum of Human Immune Disease Caused by Defective Perforin Delivery or Function
Congenital perforin deficiency is considered a rare cause of human immunopathology and immune dysregulation, and classically presents as a fatal illness early in infancy. However, we propose that a group of related disorders in which killer lymphocytes deliver only partially active perforin or a red...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Frontiers Media S.A.
2013
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3860100/ https://ncbi.nlm.nih.gov/pubmed/24376445 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2013.00441 |
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