Human perforin mutations and susceptibility to multiple primary cancers

Loss-of-function mutations in the gene coding for perforin (PRF1) markedly reduce the ability of cytotoxic T lymphocytes and natural killer cells to kill target cells, causing immunosuppression and impairing immune regulation. In humans, nearly half of the cases of type 2 familial hemophagocytic lym...

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Autors principals: Trapani, Joseph A., Thia, Kevin Y.T., Andrews, Miles, Davis, Ian D., Gedye, Craig, Parente, Philip, Svobodova, Suzanne, Chia, Jenny, Browne, Kylie, Campbell, Ian G., Phillips, Wayne A., Voskoboinik, Ilia, Cebon, Jonathan S.
Format: Artigo
Idioma:Inglês
Publicat: Landes Bioscience 2013
Matèries:
Brief Report
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3654607/
https://ncbi.nlm.nih.gov/pubmed/23734337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/onci.24185
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