Human perforin mutations and susceptibility to multiple primary cancers

Loss-of-function mutations in the gene coding for perforin (PRF1) markedly reduce the ability of cytotoxic T lymphocytes and natural killer cells to kill target cells, causing immunosuppression and impairing immune regulation. In humans, nearly half of the cases of type 2 familial hemophagocytic lym...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Trapani, Joseph A., Thia, Kevin Y.T., Andrews, Miles, Davis, Ian D., Gedye, Craig, Parente, Philip, Svobodova, Suzanne, Chia, Jenny, Browne, Kylie, Campbell, Ian G., Phillips, Wayne A., Voskoboinik, Ilia, Cebon, Jonathan S.
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2013
Assuntos:
Brief Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3654607/
https://ncbi.nlm.nih.gov/pubmed/23734337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/onci.24185
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados