Human perforin mutations and susceptibility to multiple primary cancers

Loss-of-function mutations in the gene coding for perforin (PRF1) markedly reduce the ability of cytotoxic T lymphocytes and natural killer cells to kill target cells, causing immunosuppression and impairing immune regulation. In humans, nearly half of the cases of type 2 familial hemophagocytic lym...

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Hlavní autoři: Trapani, Joseph A., Thia, Kevin Y.T., Andrews, Miles, Davis, Ian D., Gedye, Craig, Parente, Philip, Svobodova, Suzanne, Chia, Jenny, Browne, Kylie, Campbell, Ian G., Phillips, Wayne A., Voskoboinik, Ilia, Cebon, Jonathan S.
Médium: Artigo
Jazyk:Inglês
Vydáno: Landes Bioscience 2013
Témata:
Brief Report
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3654607/
https://ncbi.nlm.nih.gov/pubmed/23734337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/onci.24185
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